| The Potency Difference of Botulinum Toxin Type Aaccording to Reconstituting Media |
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| Abstract |
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Objectives: The purpose of this study is to compare the potency of botulinum toxin type A (BTA) reconstitutedwith preserved saline to that with nonpreserved saline in humans.Methods: We conducted double blinded controlled study of injecting BTA reconstituted with normalsaline to one side of extensor digitorum brevis (EDB) and BTA reconstituted with preserved saline to theother side of EDB in 11 healthy volunteers.Amplitude of the EDB compound muscle action potentials (CMAP) was compared between both sidesbefore and 1 week, 4 weeks, 8 weeks and 12 weeks after the injection.Results: At 1 week after the injection, there was no difference in potency between two sides. However,there was a significant potency difference at 4 weeks, 8 weeks and 12 weeks after the injection, showingreduced potency of BTA reconstituted with preserved saline compared to BTA reconstituted with normalsaline.Conclusion: Potency of the BTA might be reduced when it is reconstituted with preserved saline as comparedto normal saline, therefore reconstituting BTA with preserved saline should be reconsidered. |
| Key Words:
Botulinum toxin type A, Potency, Reconstitution |
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