The Change of Nerve Conduction Study Parameters in Rats by Complex Regional Pain Syndrome Model

J Korean Assoc EMG Electrodiagn Med 2005;7(1):40-44.
Published online May 10, 2005.

Abstract

Objectives: To verify the type of complex regional pain syndrome (CRPS) at Bennett and Xie’s model1 through the nerve conduction study. Method: Twenty male Sprague-Dawley rats were divided into control and experimental group. The control group had sham operations. The model of Bennett and Xie had a chronic constriction injury for the experimental group. For each group, the thickness and the temperature of the right hind paw and the weight of subjects were measured before, two weeks and four weeks after the operation. Also, the motor nerve conduction study was done in right sciatic nerve. Result: After two and four weeks of the operation, the thickness and the temperature of the right hind paw in the experimental group were significantly higher than those of the control group. In the motor nerve conduction study, the amplitude of compound muscle action potential in the experimental group was significantly decreased. Conclusion: This results suggest that Bennett and Xie’s model is CRPS type II.

Key Words: CRPS (Complex regional pain syndrome), Chronic construction injury, Nerve conduction study, Rat model, Sciatic nerve