Hereditary ‘Pure’ Spastic Paraplegia - A Case Report -

J Korean Assoc EMG Electrodiagn Med 2002;4(1):45-48.
Published online May 10, 2002.

Abstract

A family, in that 3 women are diagnosed as hereditary ‘pure’ spastic paraplegia, is presented with literature review. One of them visited the clinic complaining spastic gait pattern. There was no abnormality in the upper extremity, but there were increased deep tendon reflex, ankle clonus and spasticity in the lower extremity. The electrodiagnostic study including the somatosensory evoked potential study suggested no definite abnormality. But the motor evoked potential study (MEP) using magnetic stimulation revealed central conduction abnormality. The mode of inheritance was autosomal dominant type. One of them was consistant with type I of Harding’s classification, and two of them were consistant with type II of Harding’s classification. Recently the classification by mutations of the specific chromosomes and genes is being developed which seems to be reasonable.

Key Words: Hereditary spastic paraplegia, Pure type, MEP