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J Korean Assoc EMG Electrodiagn Med 2000;2(2):110-119.
Published online May 10, 2000.
Estimation of Normal BAEPs Latencies from Infancy to Early Childhood Using Meta-Analysis
Abstract
Objectives : The brainstem auditory evoked potentials (BAEPs) are an useful method to evaluate functions from the auditory nerve to the brainstem but there are many different test methods amongst different labs that make it difficult to compare the results. Since there are many differences associated with different test method and other reference values for the evaluation of children from the period of infancy (1~12 months) to early childhood (1 year~6 years), there is a need to establish a standardized test method with normal references. We initiated this study to overcome these difficulties. Methods : We searched through 25 sources, which had been previously published from 1974 to 1997, concerning the brainstem auditory evoked potentials in normal children from infants to early childhood. The search provided a common test method using all 25 sources and obtained a normal reference value of peak latencies and interpeak latencies through the meta-analysis technique by researching 7 sources stated normal reference values. Results : After meta-analysis from 7 sources, we found normal peak latencies and interpeak latencies of a standard 70 dB stimulation intensity, 10 Hz stimulation frequency and monoaural mode. The most common test method used active electrodes with a silver/silverchloride surface (70.6%) which was applied to the mastoid process (50%). The site for the reference electrode was the vertex (59%) and the site for the ground electrode was the contralateral mastoid process (38%) or upper forehead (29%). The interelectrode impedance was less than 5000 Ω (80%), the bandpass of filter was 100 Hz (40%)~3000 Hz (55%), the stimulation frequency was 10 Hz (71%) and the stimulation intensity was 70 dB (33%). The total stimulation number was found to be more than 1024 and the most common stimulation mode was the monoaural mode (85%). Each test was conducted more than twice on the same ear. Conclusion : Since there are many labs that have not established a normal reference value and a standardized method compared with labs in adults, the normal peak latencies and interpeak latencies suggested through meta-analysis and a common test method, may be used as a valuable reference for many labs.
Key Words: Meta-analysis, Normal latency, Infancy, Early childhood, Brainstem auditory evoked potentials
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