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J Korean Assoc EMG Electrodiagn Med 2000;2(2):95-100.
Published online May 10, 2000.
The Significance of Cognitive Evoked Potentials in Non-Insulin Dependent Diabetic Patients
Abstract
Objectives : To investigate the findings of cognitive evoked potentials in non-insulin dependent diabetes mellitus (NIDDM)patients and to correlate modified mini-mental state examination (3MS), diabetic complications, and laboratory parameters with cognitive evoked potentials. Methods : Forty-three NIDDM patients with the duration greater or equal to 5 years and thirty age-, sex, and education-matched normal controls were recruited for this study. 3MS, nerve conduction studies, cognitive evoked potential test, fluorescent angiography were performed and laboratory parameters such as serum HbA1C, triglyceride, and total cholesterol were obtained via blood sampling. Results : 1) The latencies of P300 were significantly prolonged in NIDDM patients compared with controls. 2) There was reverse correlation between the score of 3MS and the latencies of P300 in NIDDM patients. 3) The latencies of P300 were not clearly correlated with the laboratory parameters in NIDDM patients. 4) The latencies of P300 were prolonged in NIDDM patients with peripheral neuropathy and retinopathy, but, not prolonged in NIDDM patients with nephropathy. Conclusion : Cognitive function may be impaired in NIDDM patients without apparent symptoms and signs of central nerve system damage and the latencies of P300 may be useful in evaluating cognitive dysfunction objectively in NIDDM patients.
Key Words: Cognitive evoked potentials, Non-insulin dependent diabetes mellitus, Modified minimental state examination, P300


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